Heam Polymerization and its Inhibition by Antimalarial Drug: Hemozoin is considered to be a suitable target to develop new antimalarial drug - Couverture souple

Malaria is one of the most common diseases in developing countries and poses a great challenge to world health. Resistance of malaria parasites to available antimalarial drugs remains the main challenge to the effective control of the disease. The physiological conditions prevailing with in the acidic digestive vacuoles of the malaria parasites provide a suitable physiochemical environment for conversion of heam to beta-hematin/hemozoin. Though the both protein as well as lipids mediated beta-hematin formation remain valid hypothesis but later seems to be more relevant, when mechanism of hemozoin synthesis is considered as a simple physiochemical reaction. Some repeats earlier heme show loss of beta-hematin formation activity of the parasite lysate by protenase K and heat treatment. The digestion of this cytosol, which consists essentially of hemoglobin results in the formation of potentially toxic ferriprotoporphyrin IX (FP). Several antimalarial drugs are thought to exert their effect by complexing with FP, thus inhibiting its detoxification through polymerization to hemozoin. Our aim shows that inhibition of heam polymerization by Arteether.

Sanjeev Kumar Shukla is completed his Ph.D. in Biotechnology, B.U. Jhansi,U.P., India, Ramesh Chandra is completed his Ph.D. in Zoology at CDRI, Lucknow, India and S.K.Puri is a Head,Division of Parasitology, CDRI, Lucknow India.